Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator Zta
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- Yao Chang
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
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- Heng-Huan Lee
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
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- Yu-Te Chen
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
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- Jean Lu
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
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- Shih-Yi Wu
- Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
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- Chaio-Wei Chen
- Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
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- Kenzo Takada
- Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
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- Ching-Hwa Tsai
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
説明
<jats:title>ABSTRACT</jats:title> <jats:p>Early growth response 1 (Egr-1) is a cellular transcription factor involved in diverse biologic functions. Egr-1 has been associated with Epstein-Barr virus (EBV) infection, but it is still unknown whether any EBV protein regulates Egr-1 expression. In this study, we first showed that EBV reactivation is involved in upregulation of Egr-1 and that Egr-1 can be induced by Zta, an EBV lytic transactivator. Zta not only binds to the Egr-1 promoter but also activates the ERK signaling pathway to trigger binding of Elk-1 to the Egr-1 promoter. In addition, knockdown of Egr-1 significantly reduces the spontaneous expression of Zta and Rta in EBV-infected 293 cells, suggesting that a positive-feedback network involving Egr-1 is required for EBV reactivation. This study also implies that Zta has the potential to affect expression of certain genes through Egr-1.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 80 (15), 7748-7755, 2006-08
American Society for Microbiology
