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- Denis Noble
- From the Department of Physiology, Anatomy and Genetics, Oxford University, United Kingdom.
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- Penelope J. Noble
- From the Department of Physiology, Anatomy and Genetics, Oxford University, United Kingdom.
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- Martin Fink
- From the Department of Physiology, Anatomy and Genetics, Oxford University, United Kingdom.
書誌事項
- タイトル別名
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- Historical Background
抄録
<jats:p> <jats:bold> <jats:italic> <jats:underline>Abstract</jats:underline> : </jats:italic> </jats:bold> Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in the calcium-induced calcium release process. Those historical results fully support the synthesis proposed in the articles in this review series. The oscillator mechanisms do not primarily compete with each; they entrain each other. However, there is some asymmetry: the membrane oscillator can continue indefinitely in the absence of the calcium oscillator. The reverse seems to be true only in pathological conditions. Studies from tissue-level work and on the development of the heart also provide valuable insights into the integrative action of the cardiac pacemaker. </jats:p>
収録刊行物
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- Circulation Research
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Circulation Research 106 (12), 1791-1797, 2010-06-25
Ovid Technologies (Wolters Kluwer Health)
