BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
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- Marina N. Nikiforova
- Department of Pathology and Laboratory Medicine (M.N.N., M.G., P.W.B., Z.Z., Y.E.N.), Cincinnati, Ohio
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- Edna T. Kimura
- Division of Endocrinology (E.T.K., J.A.K., J.A.F.), University of Cincinnati, Cincinnati, Ohio
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- Manoj Gandhi
- Department of Pathology and Laboratory Medicine (M.N.N., M.G., P.W.B., Z.Z., Y.E.N.), Cincinnati, Ohio
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- Paul W. Biddinger
- Department of Pathology and Laboratory Medicine (M.N.N., M.G., P.W.B., Z.Z., Y.E.N.), Cincinnati, Ohio
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- Jeffrey A. Knauf
- Division of Endocrinology (E.T.K., J.A.K., J.A.F.), University of Cincinnati, Cincinnati, Ohio
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- Fulvio Basolo
- Dipartimento di Oncologia (F.B., R.G.), Pisa, Italy
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- Zhaowen Zhu
- Department of Pathology and Laboratory Medicine (M.N.N., M.G., P.W.B., Z.Z., Y.E.N.), Cincinnati, Ohio
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- Riccardo Giannini
- Dipartimento di Oncologia (F.B., R.G.), Pisa, Italy
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- Giuliana Salvatore
- Dipartimento di Biologia e Patologia Cellulare e Molecolare (G.S., A.F., M.S.), University ‘Federico II’ c/o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
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- Alfredo Fusco
- Dipartimento di Biologia e Patologia Cellulare e Molecolare (G.S., A.F., M.S.), University ‘Federico II’ c/o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
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- Massimo Santoro
- Dipartimento di Biologia e Patologia Cellulare e Molecolare (G.S., A.F., M.S.), University ‘Federico II’ c/o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
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- James A. Fagin
- Division of Endocrinology (E.T.K., J.A.K., J.A.F.), University of Cincinnati, Cincinnati, Ohio
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- Yuri E. Nikiforov
- Department of Pathology and Laboratory Medicine (M.N.N., M.G., P.W.B., Z.Z., Y.E.N.), Cincinnati, Ohio
説明
<jats:title>Abstract</jats:title> <jats:p>Activating point mutations of the BRAF gene have been recently reported in papillary thyroid carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell lines and detected BRAF mutations in 45 (38%) papillary carcinomas, two (13%) poorly-differentiated carcinomas, three (10%) anaplastic carcinomas, and five (83%) thyroid anaplastic carcinoma cell lines but not in follicular, Hürthle cell, and medullary carcinomas, follicular and Hürthle cell adenomas, or benign hyperplastic nodules. All mutations involved a T→A transversion at nucleotide 1796. In papillary carcinomas, BRAF mutations were associated with older age, classic papillary carcinoma or tall cell variant histology, extrathyroidal extension, and more frequent presentation at stages III and IV. All BRAF-positive poorly differentiated and anaplastic carcinomas contained areas of preexisting papillary carcinoma, and mutation was present in both the well-differentiated and dedifferentiated components. These data indicate that BRAF mutations are restricted to papillary carcinomas and poorly differentiated and anaplastic carcinomas arising from papillary carcinomas. They are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas.</jats:p>
収録刊行物
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- The Journal of Clinical Endocrinology & Metabolism
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The Journal of Clinical Endocrinology & Metabolism 88 (11), 5399-5404, 2003-11-01
The Endocrine Society
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詳細情報 詳細情報について
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- CRID
- 1363107369747557120
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- ISSN
- 19457197
- 0021972X
- http://id.crossref.org/issn/0021972X
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- データソース種別
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- Crossref