Amyloid precursor protein and neural development

DOI PDF 4 Citations
  • Maya Nicolas
    VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium
  • Bassem A. Hassan
    VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium

Description

<jats:p>Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests that understanding the basic biology of APP and its physiological role during development might be a crucial missing link for a better comprehension of Alzheimer's disease. Here, we present an overview of some of the key studies performed in various model organisms that have revealed roles for APP at different stages of neuronal development.</jats:p>

Journal

  • Development

    Development 141 (13), 2543-2548, 2014-07-01

    The Company of Biologists

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