Lassa Virus Z Protein Is a Matrix Protein Sufficient for the Release of Virus-Like Particles
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- Thomas Strecker
- Institut für Virologie der Philipps-Universität Marburg, D-35037 Marburg, Germany
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- Robert Eichler
- Institut für Virologie der Philipps-Universität Marburg, D-35037 Marburg, Germany
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- Jan ter Meulen
- Institut für Virologie der Philipps-Universität Marburg, D-35037 Marburg, Germany
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- Winfried Weissenhorn
- European Molecular Biology Laboratory (EMBL), Grenoble Outstation, 38000 Grenoble, France
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- Hans Dieter Klenk
- Institut für Virologie der Philipps-Universität Marburg, D-35037 Marburg, Germany
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- Wolfgang Garten
- Institut für Virologie der Philipps-Universität Marburg, D-35037 Marburg, Germany
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- Oliver Lenz
- European Molecular Biology Laboratory (EMBL), Grenoble Outstation, 38000 Grenoble, France
説明
<jats:title>ABSTRACT</jats:title> <jats:p>Lassa virus is an enveloped virus with glycoprotein spikes on its surface. It contains an RNA ambisense genome that encodes the glycoprotein precursor GP-C, the nucleoprotein NP, the polymerase L, and the Z protein. Here we demonstrate that the Lassa virus Z protein (i) is abundant in viral particles, (ii) is strongly membrane associated, (iii) is sufficient in the absence of all other viral proteins to release enveloped particles, and (iv) contains two late domains, PTAP and PPXY, necessary for the release of virus-like particles. Our data provide evidence that Z is the Lassa virus matrix protein that is the driving force for virus particle release.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 77 (19), 10700-10705, 2003-10
American Society for Microbiology
