Survival outcomes for stage‐matched endoscopic and open resection of olfactory neuroblastoma
-
- Richard J. Harvey
- Applied Medical Research Centre University of New South Wales Kensington Australia
-
- Sunny Nalavenkata
- Applied Medical Research Centre University of New South Wales Kensington Australia
-
- Raymond Sacks
- Applied Medical Research Centre University of New South Wales Kensington Australia
-
- Nithin D. Adappa
- Department of Otorhinolaryngology/ Head & Neck Surgery University of Pennsylvania Philadelphia Pennsylvania
-
- James N. Palmer
- Department of Otorhinolaryngology/ Head & Neck Surgery University of Pennsylvania Philadelphia Pennsylvania
-
- Michael T. Purkey
- Department of Otorhinolaryngology/ Head & Neck Surgery University of Pennsylvania Philadelphia Pennsylvania
-
- Rodney J. Schlosser
- Department of Otolaryngology ‐ Head and Neck Surgery Medical University of South Carolina Charleston South Carolina
-
- Carl Snyderman
- Department of Otolaryngology/ Head & Neck Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania
-
- Eric W. Wang
- Department of Otolaryngology/ Head & Neck Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania
-
- Bradford A. Woodworth
- Department of Otolaryngology University of Alabama at Birmingham Birmingham Alabama
-
- Robert Smee
- Department of Radiation Oncology The Prince of Wales Cancer Centre Prince of Wales Australia
-
- Tom Havas
- Department of Otolaryngology, Head and Neck Surgery The Prince of Wales Cancer Centre and Hospital Prince of Wales Australia
-
- Richard Gallagher
- Department of Otolaryngology ‐ Head and Neck, Skull Base Surgery St Vincent's Hospital Fitzroy Victoria Australia
Description
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Advanced‐stage olfactory neuroblastoma requires multimodal therapy for optimal outcomes. Debate exists over endoscopic endonasal surgery in this situation. Stage‐matched open and endoscopic surgical therapy were compared.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients from 6 cancer institutions were assessed. Stratification included dural involvement, Kadish stage, nodal disease, Hyams' grade, approach, and margin status. At follow‐up, local control, nodal status, and evidence of distant metastases were recorded with any subsequent therapy. Statistical analyses to identify risk factors for developing recurrence and survival differences were performed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>One hundred nine patients were assessed (age 49.2 ± 13.0 years; 46% women) representing Kadish A stage (10%), Kadish B stage (25%), and Kadish C stage (65%). The majority of the patients (61.5%) underwent endoscopic resection, 53.5% within Kadish C stage. Within‐stage survival analysis favored endoscopic subgroup for Kadish C stage (log‐rank <jats:italic>P</jats:italic> = .017) nonsignificant for Kadish B stage (log‐rank <jats:italic>P</jats:italic> = .39).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Stage‐matched survival was better for the endoscopically treated group compared to the open surgery group, with high negative margin resections obtained.</jats:p></jats:sec>
Journal
-
- Head & Neck
-
Head & Neck 39 (12), 2425-2432, 2017-09-25
Wiley
- Tweet
Details 詳細情報について
-
- CRID
- 1363107369842243968
-
- ISSN
- 10970347
- 10433074
-
- Data Source
-
- Crossref