Initial depression severity and response to antidepressants <i>v.</i> placebo: patient-level data analysis from 34 randomised controlled trials
説明
<jats:title>Summary</jats:title><jats:p>Several often-cited meta-analyses have reported that the efficacy of antidepressant medications depends on the severity of depression. They found that drug–placebo differences increased as a function of initial severity, which was attributed to decreased responsiveness to placebo among patients with severe depression rather than to increased responsiveness to medication. We retested this using patient-level data and also undertaking a meta-analysis of trial-level data from 34 randomised placebo controlled trials (<jats:italic>n</jats:italic> = 10 737) from the NEWMEDS registry. Although our trial-level data support prevous findings, patient-level data did not show any significant effect of initial depression severity on drug <jats:italic>v.</jats:italic> placebo difference.</jats:p>
収録刊行物
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- British Journal of Psychiatry
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British Journal of Psychiatry 209 (5), 427-428, 2016-11
Royal College of Psychiatrists