SINTAX: a simple non-Bayesian taxonomy classifier for 16S and ITS sequences

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Description

<jats:title>Abstract</jats:title><jats:p>Metagenomics experiments often characterize microbial communities by sequencing the ribosomal 16S and ITS regions. Taxonomy prediction is a fundamental step in such studies. The SINTAX algorithm predicts taxonomy by using<jats:italic>k</jats:italic>-mer similarity to identify the top hit in a reference database and provides bootstrap confidence for all ranks in the prediction. SINTAX achieves comparable or better accuracy to the RDP Naive Bayesian Classifier with a simpler algorithm that does not require training. Most tested methods are shown to have high rates of over-classification errors where novel taxa are incorrectly predicted to have known names.</jats:p>

Journal

  • bioRxiv

    bioRxiv 2016-09-09

    Cold Spring Harbor Laboratory

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