Synthesis of Polyester by Means of Genetic Code Reprogramming

DOI Web Site Web Site PubMed 被引用文献50件 オープンアクセス

説明

Here we report the ribosomal polymerization of alpha-hydroxy acids by means of genetic code reprogramming. The flexizyme system, a ribozyme-based tRNA acylation tool, was used to re-assign individual codons to seven types of alpha-hydroxy acids, and then polyesters were synthesized under controls of the reprogrammed genetic code using a reconstituted cell-free translation system. The sequence and length of the polyester segments were specified by the mRNA template, indicating that high-fidelity ribosome expression of polyesters was possible. This work opens a door for the mRNA-directed synthesis of backbone-altered biopolymers.

収録刊行物

被引用文献 (50)*注記

もっと見る

キーワード

問題の指摘

ページトップへ