Postnatal Neurodevelopmental Disorders: Meeting at the Synapse?

DOI Web Site 18 Citations
  • Huda Y. Zoghbi
    Departments of Pediatrics, Neurology, and Molecular and Human Genetics, Division of Neuroscience, and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.

Description

<jats:p>We often think of neurodevelopmental disorders as beginning before birth, and many certainly do. A handful, however, strike many months after birth, following a period of apparently normal growth and development. Autism and Rett syndrome are two such disorders, and here I consider some of their similarities at the phenotypic and pathogenic levels. I propose that both disorders result from disruption of postnatal or experience-dependent synaptic plasticity.</jats:p>

Journal

  • Science

    Science 302 (5646), 826-830, 2003-10-31

    American Association for the Advancement of Science (AAAS)

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