Sleep disturbances and dementia risk: A multicenter study
-
- Shireen Sindi
- Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
-
- Ingemar Kåreholt
- Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
-
- Lena Johansson
- Institute of Neuroscience and Physiology Center for Health and Ageing AGECAP Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
-
- Johan Skoog
- Institute of Neuroscience and Physiology Center for Health and Ageing AGECAP Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
-
- Linnea Sjöberg
- Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
-
- Hui‐Xin Wang
- Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
-
- Boo Johansson
- Department of Psychology Center for Health and Ageing AGECAP University of Gothenburg Gothenburg Sweden
-
- Laura Fratiglioni
- Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
-
- Hilkka Soininen
- Institute of Clinical Medicine Neurology University of Eastern Finland Kuopio Finland
-
- Alina Solomon
- Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden
-
- Ingmar Skoog
- Institute of Neuroscience and Physiology Center for Health and Ageing AGECAP Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
-
- Miia Kivipelto
- Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden
説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Sleep disturbances were assessed in three population‐based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late‐life baseline analyses (3–10 years follow‐up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow‐up) (N = 1407).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02–1.50) and late‐life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08–3.49) were associated with a higher dementia risk. Late‐life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87–8.48).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Midlife insomnia and late‐life terminal insomnia or long sleep duration were associated with a higher late‐life dementia risk.</jats:p></jats:sec>
収録刊行物
-
- Alzheimer's & Dementia
-
Alzheimer's & Dementia 14 (10), 1235-1242, 2018-07-17
Wiley
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1363107370298705664
-
- ISSN
- 15525279
- 15525260
-
- Web Site
- https://api.elsevier.com/content/article/PII:S1552526018302188?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S1552526018302188?httpAccept=text/plain
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.jalz.2018.05.012
- https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.jalz.2018.05.012
- https://onlinelibrary.wiley.com/doi/full-xml/10.1016/j.jalz.2018.05.012
-
- データソース種別
-
- Crossref