Sleep disturbances and dementia risk: A multicenter study

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  • Shireen Sindi
    Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
  • Ingemar Kåreholt
    Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
  • Lena Johansson
    Institute of Neuroscience and Physiology Center for Health and Ageing AGECAP Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
  • Johan Skoog
    Institute of Neuroscience and Physiology Center for Health and Ageing AGECAP Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
  • Linnea Sjöberg
    Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
  • Hui‐Xin Wang
    Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
  • Boo Johansson
    Department of Psychology Center for Health and Ageing AGECAP University of Gothenburg Gothenburg Sweden
  • Laura Fratiglioni
    Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
  • Hilkka Soininen
    Institute of Clinical Medicine Neurology University of Eastern Finland Kuopio Finland
  • Alina Solomon
    Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden
  • Ingmar Skoog
    Institute of Neuroscience and Physiology Center for Health and Ageing AGECAP Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
  • Miia Kivipelto
    Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden

説明

<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Sleep disturbances were assessed in three population‐based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late‐life baseline analyses (3–10 years follow‐up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow‐up) (N = 1407).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02–1.50) and late‐life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08–3.49) were associated with a higher dementia risk. Late‐life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87–8.48).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Midlife insomnia and late‐life terminal insomnia or long sleep duration were associated with a higher late‐life dementia risk.</jats:p></jats:sec>

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