Nanosims Imaging: An Approach for Visualizing and Quantifying Lipids in Cells and Tissues

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  • Cuiwen He
    Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
  • Loren G Fong
    Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
  • Stephen G Young
    Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
  • Haibo Jiang
    Centre for Microscopy, Characterisation, and Analysis, The University of Western Australia, Perth, Western Australia, Australia

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<jats:p> Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity. </jats:p>

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