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- David W. Dunstan
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
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- Bronwyn A. Kingwell
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
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- Robyn Larsen
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
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- Genevieve N. Healy
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
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- Ester Cerin
- Institute of Human Performance, The University of Hong Kong, Hong Kong
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- Marc T. Hamilton
- Pennington Biomedical Research Center, Baton Rouge, Louisiana
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- Jonathan E. Shaw
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
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- David A. Bertovic
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
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- Paul Z. Zimmet
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
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- Jo Salmon
- School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia
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- Neville Owen
- Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
抄録
<jats:sec> <jats:title /> <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Overweight/obese adults (n = 19), aged 45–65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95% CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>The glucose iAUC (mmol/L) ⋅ h after both activity-break conditions was reduced (light: 5.2 [4.1–6.6]; moderate: 4.9 [3.8–6.1]; both P < 0.01) compared with uninterrupted sitting (6.9 [5.5–8.7]). Insulin iAUC (pmol/L) ⋅ h was also reduced with both activity-break conditions (light: 633.6 [552.4–727.1]; moderate: 637.6 [555.5–731.9], P < 0.0001) compared with uninterrupted sitting (828.6 [722.0–950.9]).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.</jats:p> </jats:sec> </jats:sec>
収録刊行物
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- Diabetes Care
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Diabetes Care 35 (5), 976-983, 2012-04-11
American Diabetes Association
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詳細情報 詳細情報について
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- CRID
- 1363107370590634752
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- ISSN
- 19355548
- 01495992
- http://id.crossref.org/issn/01495992
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- データソース種別
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- Crossref