Circulating Tumor Cells: Evolving Evidence and Future Challenges

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  • Efrat Dotan
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
  • Steven J. Cohen
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
  • Katherine R. Alpaugh
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
  • Neal J. Meropol
    Division of Hematology-Oncology, University Hospitals Case Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA

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Description

<jats:title>Abstract</jats:title> <jats:p>Circulating tumor cells (CTCs) are rare malignant cells found in the peripheral blood that originate from the primary tumor or metastatic sites. New techniques have been developed to isolate and characterize these cells. CTC enumeration has been incorporated into different fields of oncology as a prognostic marker, a tool to monitor therapy response, and a method to understand basic tumor characteristics. This review covers the different techniques available for isolation of CTCs, the clinical utility of CTCs in breast, prostate, and colon cancer, and future directions in this field.</jats:p>

Journal

  • The Oncologist

    The Oncologist 14 (11), 1070-1082, 2009-11-01

    Oxford University Press (OUP)

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