Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

DOI Web Site 12 Citations
  • Martijn J. Schuijs
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
  • Monique A. Willart
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
  • Karl Vergote
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
  • Delphine Gras
    Department of Respiratory Medicine, Assistance Publique Hopitaux de Marseille, UMR INSERM U1067 CNRS 7333, Aix Marseille University, Marseille, France.
  • Kim Deswarte
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
  • Markus J. Ege
    Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
  • Filipe Branco Madeira
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
  • Rudi Beyaert
    Unit of Molecular Signal Transduction, VIB Inflammation Research Center, Ghent, Belgium.
  • Geert van Loo
    Unit of Molecular Signal Transduction, VIB Inflammation Research Center, Ghent, Belgium.
  • Franz Bracher
    Center for Drug Research, Department of Pharmacy, Ludwig Maximilians University, Butenandtstrasse 5-13, D-81377 Munich, Germany.
  • Erika von Mutius
    Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
  • Pascal Chanez
    Department of Respiratory Medicine, Assistance Publique Hopitaux de Marseille, UMR INSERM U1067 CNRS 7333, Aix Marseille University, Marseille, France.
  • Bart N. Lambrecht
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
  • Hamida Hammad
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.

Description

<jats:title>How farming protects against allergies</jats:title> <jats:p> People who grow up on dairy farms only rarely develop asthma or allergies. This is probably because as children, they breathe air containing bacterial components, which reduce the overall reactivity of the immune system. Schuijs <jats:italic>et al.</jats:italic> chronically exposed mice to bacterial endotoxin before they received an allergic stimulus. The protocol indeed protected them from developing an allergic response. Protection relied on a particular enzyme: A20. In humans, a variant of A20 correlates with increased susceptibility to asthma and allergy in children growing up on farms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6252" page="1106" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac6623">1106</jats:related-article> </jats:p>

Journal

  • Science

    Science 349 (6252), 1106-1110, 2015-09-04

    American Association for the Advancement of Science (AAAS)

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