Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
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- Csaba Cserép
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Balázs Pósfai
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Nikolett Lénárt
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Rebeka Fekete
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Zsófia I. László
- Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, Hungary.
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- Zsolt Lele
- Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Budapest, Hungary.
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- Barbara Orsolits
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Gábor Molnár
- MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
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- Steffanie Heindl
- Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany.
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- Anett D. Schwarcz
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Katinka Ujvári
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Zsuzsanna Környei
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Krisztina Tóth
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Eszter Szabadits
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Beáta Sperlágh
- Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary.
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- Mária Baranyi
- Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary.
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- László Csiba
- MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, Debrecen, Hungary.
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- Tibor Hortobágyi
- Institute of Pathology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
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- Zsófia Maglóczky
- Human Brain Research Laboratory, Institute of Experimental Medicine, Budapest, Hungary.
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- Bernadett Martinecz
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
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- Gábor Szabó
- Medical Gene Technology Unit, Institute of Experimental Medicine, Budapest, Hungary.
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- Ferenc Erdélyi
- Medical Gene Technology Unit, Institute of Experimental Medicine, Budapest, Hungary.
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- Róbert Szipőcs
- Institute for Solid State Physics and Optics of Wigner RCP, Budapest, Hungary.
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- Michael M. Tamkun
- Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
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- Benno Gesierich
- Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany.
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- Marco Duering
- Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany.
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- István Katona
- Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Budapest, Hungary.
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- Arthur Liesz
- Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany.
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- Gábor Tamás
- MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
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- Ádám Dénes
- Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
説明
<jats:title>Microglia take control</jats:title> <jats:p> Changes in the activity of microglia, the primary immune cells of the central nervous system, are linked with major human diseases, including stroke, epilepsy, psychiatric disorders, and neurodegeneration. Cserép <jats:italic>et al.</jats:italic> identified a specialized morphofunctional communication site between microglial processes and neuronal cell bodies in the mouse and the human brain (see the Perspective by Nimmerjahn). These junctions are formed at specific areas of the neuronal somatic membranes and possess a distinctive nanoarchitecture and specialized molecular composition linked to mitochondrial signaling. The junctions appear to provide a major site for microglia-neuron communication and may help to mediate the neuroprotective effects of microglia after acute brain injury. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6477" page="528" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax6752">528</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6477" page="510" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aba4472">510</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 367 (6477), 528-537, 2020-01-31
American Association for the Advancement of Science (AAAS)