Life-Long Wheel Running Attenuates Age-Related Fiber Loss in the Plantaris Muscle of Mice: a Pilot Study

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  • M. Suwa
    Toyota Motor Coporation, Health Support Center WELPO, Toyota, Japan
  • T. Ishioka
    Tohoku Institute of Technology, Faculty of Life Design, Sendai, Japan
  • J. Kato
    Tohoku Institute of Technology, Faculty of Life Design, Sendai, Japan
  • J. Komaita
    Tohoku Institute of Technology, Faculty of Life Design, Sendai, Japan
  • T. Imoto
    Toyota Motor Coporation, Health Support Center WELPO, Toyota, Japan
  • A. Kida
    Toyota Motor Coporation, Health Support Center WELPO, Toyota, Japan
  • T. Yokochi
    Toyota Motor Coporation, Health Support Center WELPO, Toyota, Japan

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The purpose of this study was to investigate whether long-term wheel running would attenuate age-related loss of muscle fiber. Male ICR mice were divided into young (Y, n=12, aged 3 months), old-sedentary (OS, n=5, aged 24 months), and old-exercise (OE, n=6, aged 24 months) groups. The OE group started spontaneous wheel running at 3 months and continued until 24 months of age. Soleus and plantaris muscles were fixed in 4% paraformaldehyde buffer. The fixed muscle was digested in a 50% NaOH solution to isolate single fiber and then fiber number was quantified. The masses of the soleus and plantaris muscles were significantly lower at 24 months than at 3 months of age, and this age-related difference was attenuated by wheel running (P0.05). Soleus muscle fiber number did not differ among the groups. In the plantaris muscle, the fiber number in the OS group (1 288±92 fibers) was significantly lower than in the Y group (1 874±93 fibers), and this decrease was attenuated in the OE group (1 591±80 fibers) (P0.05). These results suggest that age-related fiber loss occurs only in the fast-twitch fiber-rich muscle of mice, and that life-long wheel running exercise can prevent this fiber loss.

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