Physiological and Molecular Basis of Thyroid Hormone Action

DOI Web Site 51 Citations
  • Paul M. Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland

Description

<jats:p>Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and physiological function of virtually all tissues. TH binds to receptors that are ligand-regulatable transcription factors belonging to the nuclear hormone receptor superfamily. Tremendous progress has been made recently in our understanding of the molecular mechanisms that underlie TH action. In this review, we present the major advances in our knowledge of the molecular mechanisms of TH action and their implications for TH action in specific tissues, resistance to thyroid hormone syndrome, and genetically engineered mouse models.</jats:p>

Journal

  • Physiological Reviews

    Physiological Reviews 81 (3), 1097-1142, 2001-07-01

    American Physiological Society

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