The UV/Visible Radiation Boundary Region (385–405 nm) Damages Skin Cells and Induces “dark” Cyclobutane Pyrimidine Dimers in Human Skin in vivo
抄録
<jats:title>Abstract</jats:title><jats:p>The adverse effects of terrestrial solar ultraviolet radiation (UVR) (~295–400 nm) on the skin are well documented, especially in the UVB region (~295–320 nm). The effects of very long-wave UVA (>380 nm) and visible radiation (≥400 nm) are much less known. Sunscreens have been beneficial in inhibiting a wide range of photodamage, however most formulations provide very little protection in the long wave UVA region (380–400 nm) and almost none from shortwave visible wavelengths (400–420 nm). We demonstrate photodamage in this region for a number of different endpoints including cell viability, DNA damage (delayed cyclobutane pyrimidine dimers), differential gene expression (for genes associated with inflammation, oxidative stress and photoageing) and induction of oxidizing species <jats:italic>in vitro</jats:italic> in HaCaT keratinocytes and <jats:italic>in vivo</jats:italic> in human volunteers. This work has implications for phototherapy and photoprotection.</jats:p>
収録刊行物
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- Scientific Reports
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Scientific Reports 8 (1), 1-, 2018-08-24
Springer Science and Business Media LLC