Short and Long Sleep Durations are Both Associated with Increased Risk of Stroke: A Meta-Analysis of Observational Studies

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  • Beihai Ge
    Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • Xiaomei Guo
    Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

説明

<jats:sec><jats:title>Background</jats:title><jats:p> There is uncertainty about the relationship between sleep duration and stroke risk. Aim We aimed to clarify the relationship between sleep duration and risk of stroke by using epidemiological evidence. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We searched MEDLINE and EMBASE to identify all studies that might be looking at the association between sleep duration and stroke, including both cohort and cross-sectional studies. Pooled hazard ratios (HRs) and odds ratios (ORs) were calculated through a random-effects model. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Our study included a total of 12 cohort studies and 6 cross-sectional studies. Pooled results from the cohort studies showed that short sleep duration was associated with a higher risk for stroke [HR, 1·13; 95% confidence interval (CI) 1·02–1·25], and that long sleep duration also increases the risk of having a stroke (HR, 1·40; 95% CI, 1·16–1·64). Results from cross-sectional studies confirmed the relationship between stroke and inappropriate sleep duration, either too little sleep or too much. For short sleep duration, the OR was 1·71 (1·39–2·02); for long sleep duration, the OR was 2·12 (1·51–2·73). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Both short and long sleep durations have a significant association with higher risk of stroke. </jats:p></jats:sec>

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