Amine‐Activated Iron Catalysis: Air‐ and Moisture‐Stable Alkene and Alkyne Hydrofunctionalization

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  • Amy J. Challinor
    EaStCHEM School of Chemistry University of Edinburgh David Brewster Road Edinburgh EH9 3FJ U.K.
  • Marc Calin
    EaStCHEM School of Chemistry University of Edinburgh David Brewster Road Edinburgh EH9 3FJ U.K.
  • Gary S. Nichol
    EaStCHEM School of Chemistry University of Edinburgh David Brewster Road Edinburgh EH9 3FJ U.K.
  • Neil B. Carter
    Syngenta Jealott's Hill Research Centre, Bracknell Berkshire RG42 6EX U.K.
  • Stephen P. Thomas
    EaStCHEM School of Chemistry University of Edinburgh David Brewster Road Edinburgh EH9 3FJ U.K.

Abstract

<jats:title>Abstract</jats:title><jats:p>A simple alkylamine [(<jats:italic>i</jats:italic>Pr)<jats:sub>2</jats:sub>NEt] has been used to activate an air‐ and moisture‐stable iron(II) pre‐catalyst for alkene and alkyne hydrofunctionalization reactions. This amine activation has enabled the highly operationally simple hydrosilylation and hydroboration of alkenes and alkynes using just 0.25–2 mol% iron catalyst and 1–25 mol% amine. Significantly, these reactions proceed in equal yield under both air and inert reaction conditions.</jats:p><jats:p><jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/png" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/adsc201600570-toc-0001-m.png"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text> </jats:p>

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