Omega-3 Fatty Acids Ameliorate Atherosclerosis by Favorably Altering Monocyte Subsets and Limiting Monocyte Recruitment to Aortic Lesions

DOI Web Site 被引用文献2件
  • Amanda L. Brown
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • Xuewei Zhu
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • Shunxing Rong
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • Swapnil Shewale
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • Jeongmin Seo
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • Elena Boudyguina
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • Abraham K. Gebre
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • Martha A. Alexander-Miller
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.
  • John S. Parks
    From the Departments of Pathology-Section on Lipid Sciences (A.L.B., X.Z., S.R., S.S., J.S., E.B., A.K.G., J.S.P.), Biochemistry (J.S.P.), Microbiology and Immunology (M.A.A.-M.), Wake Forest School of Medicine, Winston-Salem, NC.

抄録

<jats:sec> <jats:title>Objective—</jats:title> <jats:p>Fish oil, containing omega-3 fatty acids, attenuates atherosclerosis. We hypothesized that omega-3 fatty acid–enriched oils are atheroprotective through alteration of monocyte subsets and their trafficking into atherosclerotic lesions.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> Low–density lipoprotein receptor knockout and apolipoprotein E <jats:sup>−/−</jats:sup> mice were fed diets containing 10% (calories) palm oil and 0.2% cholesterol, supplemented with an additional 10% palm oil, echium oil (containing 18:4 n-3), or fish oil. Compared with palm oil–fed low–density lipoprotein receptor knockout mice, echium oil and fish oil significantly reduced plasma cholesterol, splenic Ly6C <jats:sup>hi</jats:sup> monocytosis by ≈50%, atherosclerosis by 40% to 70%, monocyte trafficking into the aortic root by ≈50%, and atherosclerotic lesion macrophage content by 30% to 44%. In contrast, atherosclerosis and monocyte trafficking into the artery wall was not altered by omega-3 fatty acids in apolipoprotein E <jats:sup>−/−</jats:sup> mice; however, Ly6C <jats:sup>hi</jats:sup> splenic monocytes positively correlated with aortic root intimal area across all diet groups. In apolipoprotein E <jats:sup>−/−</jats:sup> mice, fish oil reduced the percentage of blood Ly6C <jats:sup>hi</jats:sup> monocytes, despite an average 2-fold higher plasma cholesterol relative to palm oil. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion—</jats:title> <jats:p> The presence of splenic Ly6C <jats:sup>hi</jats:sup> monocytes parallels the appearance of atherosclerotic disease in both low–density lipoprotein receptor knockout and apolipoprotein E <jats:sup>−/−</jats:sup> mice. Furthermore, omega-3 fatty acids favorably alter monocyte subsets independently from effects on plasma cholesterol and reduce monocyte recruitment into atherosclerotic lesions. </jats:p> </jats:sec>

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