PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

DOI Web Site 6 Citations
  • Taiji Tsunemi
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Travis D. Ashe
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Bradley E. Morrison
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Kathryn R. Soriano
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
  • Jonathan Au
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
  • Ruben A. Vázquez Roque
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
  • Eduardo R. Lazarowski
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Vincent A. Damian
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
  • Eliezer Masliah
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
  • Albert R. La Spada
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

Description

<jats:p>PGC-1α rescues Huntington’s disease neurodegeneration by reducing reactive oxygen species and inducing a master regulator of autophagy.</jats:p>

Journal

  • Science Translational Medicine

    Science Translational Medicine 4 (142), 142ra197-, 2012-07-11

    American Association for the Advancement of Science (AAAS)

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