Ergothioneine – a diet‐derived antioxidant with therapeutic potential
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- Barry Halliwell
- Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore (NUS) Singapore
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- Irwin K. Cheah
- Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore (NUS) Singapore
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- Richard M. Y. Tang
- National University of Singapore Graduate School for Integrative Sciences and Engineering Singapore Singapore
抄録
<jats:p>Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria. Nonetheless, it is avidly taken up from the diet by humans and other animals through a transporter, <jats:styled-content style="fixed-case">OCTN</jats:styled-content>1, and accumulates to high levels in certain tissues. Ergothioneine is not rapidly metabolised, or excreted in urine and is present in many, if not all, human tissues and body fluids. Ergothioneine has powerful antioxidant and cytoprotective properties <jats:italic>in vitro</jats:italic> and there is evidence that the body may concentrate it at sites of tissue injury by raising <jats:styled-content style="fixed-case">OCTN</jats:styled-content>1 levels. Decreased blood and/or plasma levels of ergothioneine have been observed in some diseases, suggesting that a deficiency could be relevant to the disease onset or progression. This brief Review explores the possible roles of ergothioneine in human health and disease.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 592 (20), 3357-3366, 2018-06-15
Wiley