RAGE in the pathophysiology of skeletal muscle

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  • Francesca Riuzzi
    Department of Experimental Medicine University of Perugia Perugia Italy
  • Guglielmo Sorci
    Department of Experimental Medicine University of Perugia Perugia Italy
  • Roberta Sagheddu
    Department of Experimental Medicine University of Perugia Perugia Italy
  • Sara Chiappalupi
    Department of Experimental Medicine University of Perugia Perugia Italy
  • Laura Salvadori
    Department of Experimental Medicine University of Perugia Perugia Italy
  • Rosario Donato
    Department of Experimental Medicine University of Perugia Perugia Italy

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<jats:title>Abstract</jats:title><jats:p>Emerging evidence suggests that the signalling of the <jats:italic>Receptor for Advanced Glycation End products</jats:italic> (RAGE) is critical for skeletal muscle physiology controlling both the activity of muscle precursors during skeletal muscle development and the correct time of muscle regeneration after acute injury. On the other hand, the aberrant re‐expression/activity of RAGE in adult skeletal muscle is a hallmark of muscle wasting that occurs in response to ageing, genetic disorders, inflammatory conditions, cancer, and metabolic alterations. In this review, we discuss the mechanisms of action and the ligands of RAGE involved in myoblast differentiation, muscle regeneration, and muscle pathological conditions. We highlight potential therapeutic strategies for targeting RAGE to improve skeletal muscle function.</jats:p>

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