Molecular cloning and amino acid sequence of leukotriene A4 hydrolase.

DOI Web Site 被引用文献6件
  • C D Funk
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden.
  • O Rådmark
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden.
  • J Y Fu
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden.
  • T Matsumoto
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden.
  • H Jörnvall
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden.
  • T Shimizu
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden.
  • B Samuelsson
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden.

この論文をさがす

説明

<jats:p>A cDNA clone corresponding to leukotriene A4 hydrolase was isolated from a human lung lambda gt11 expression library by immunoscreening with a polyclonal antiserum. Several additional clones from human lung and placenta cDNA lambda g11 libraries were obtained by plaque hybridization with the 32P-labeled lung cDNA clone. One of these clones has an insert of 1910 base pairs that contains the complete protein-coding region. From the deduced primary structure, leukotriene A4 hydrolase is a 610 amino and protein with a calculated molecular weight of 69,140. No apparent homologies with microsomal epoxide hydrolases were found. RNA blot analysis indicated substantial amounts of a discrete mRNA of approximately equal to 2250 nucleotides in lung tissue and leukocytes.</jats:p>

収録刊行物

被引用文献 (6)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ