Phototherapy for the treatment of cutaneous graft versus host disease

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<jats:title>Abstract</jats:title><jats:p>Graft versus host disease (<jats:styled-content style="fixed-case">GvHD</jats:styled-content>) occurs in half the patients who receive allogenic haematopoietic stem cell transplantation and is a major contributor for the morbidity and mortality in these patients. Immunosuppressant therapy cannot suppress all the manifestations of <jats:styled-content style="fixed-case">GvHD</jats:styled-content> and new ways of treating the condition are needed. The focus of this review is the treatment of cutaneous <jats:styled-content style="fixed-case">GvHD</jats:styled-content> through phototherapy. Of the six acute and ten chronic cutaneous <jats:styled-content style="fixed-case">GvHD</jats:styled-content> case series examined the overall trend was that phototherapy was able to reduce the presence of cutaneous lesions of <jats:styled-content style="fixed-case">GvHD</jats:styled-content> and, as a consequence, steroid use could be reduced. This provides a positive outlook for phototherapy as a treatment for cutaneous <jats:styled-content style="fixed-case">GvHD</jats:styled-content> but there is a need for future studies to include larger numbers of patients in order to obtain more data.</jats:p>

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