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- G. Shohat-Ophir
- Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA.
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- K. R. Kaun
- Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA.
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- R. Azanchi
- Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA.
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- H. Mohammed
- Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA.
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- U. Heberlein
- Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA.
書誌事項
- 公開日
- 2012-03-16
- DOI
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- 10.1126/science.1215932
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Toward Addiction</jats:title> <jats:p> Addiction can result when substances, such as drugs or alcohol, co-opt the brain's natural reward system. <jats:bold> Shohat-Ophir <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1351" related-article-type="in-this-issue" vol="335" xlink:href="10.1126/science.1215932">1351</jats:related-article> ; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6074" page="1309" related-article-type="in-this-issue" vol="335" xlink:href="10.1126/science.1220225">Zars</jats:related-article> </jats:bold> ) explored this potential in <jats:italic>Drosophila</jats:italic> by examining the relationship between the natural reward stimulated by mating and the unnatural reward offered by ethanol consumption. Males deprived of mating increased consumption of ethanol, and, when permitted to mate following deprivation, their ethanol consumption decreased. At a mechanistic level, mating increased the neurotransmitter neuropeptide F (NPF), while mate deprivation decreased NPF levels. </jats:p>
収録刊行物
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- Science
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Science 335 (6074), 1351-1355, 2012-03-16
American Association for the Advancement of Science (AAAS)