Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
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- Richard Y. Ebright
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Sooncheol Lee
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Ben S. Wittner
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Kira L. Niederhoffer
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Benjamin T. Nicholson
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Aditya Bardia
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Samuel Truesdell
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Devon F. Wiley
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Benjamin Wesley
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Selena Li
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Andy Mai
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Nicola Aceto
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Nicole Vincent-Jordan
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Annamaria Szabolcs
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Brian Chirn
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Johannes Kreuzer
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Valentine Comaills
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Mark Kalinich
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Wilhelm Haas
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- David T. Ting
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Mehmet Toner
- Center for Bioengineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
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- Shobha Vasudevan
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Daniel A. Haber
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Shyamala Maheswaran
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
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- Douglas S. Micalizzi
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
書誌事項
- 公開日
- 2020-03-27
- DOI
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- 10.1126/science.aay0939
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Metastasis: A matter of translation?</jats:title> <jats:p> Solid tumors shed a small number of cancer cells into the bloodstream, some of which are believed to contribute to metastasis. The molecular features that confer these circulating tumor cells (CTCs) with metastatic potential are poorly understood. Ebright <jats:italic>et al.</jats:italic> studied CTCs from breast cancer patients and found that cells with increased expression levels of certain ribosomal proteins and regulators of translation had greater metastatic capacity in a mouse model (see the Perspective by Ma and Jeffrey). Consistent with this finding, patients with higher levels of this subset of CTCs tended to have a poorer prognosis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6485" page="1468" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aay0939">1468</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6485" page="1424" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.abb0736">1424</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 367 (6485), 1468-1473, 2020-03-27
American Association for the Advancement of Science (AAAS)