Large Porous Particles for Pulmonary Drug Delivery

DOI Web Site 被引用文献28件
  • David A. Edwards
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Justin Hanes
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Giovanni Caponetti
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Jeffrey Hrkach
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Abdelaziz Ben-Jebria
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Mary Lou Eskew
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Jeffrey Mintzes
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Daniel Deaver
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Noah Lotan
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.
  • Robert Langer
    D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.

書誌事項

公開日
1997-06-20
DOI
  • 10.1126/science.276.5320.1868
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>A new type of inhalation aerosol, characterized by particles of small mass density and large size, permitted the highly efficient delivery of inhaled therapeutics into the systemic circulation. Particles with mass densities less than 0.4 gram per cubic centimeter and mean diameters exceeding 5 micrometers were inspired deep into the lungs and escaped the lungs' natural clearance mechanisms until the inhaled particles delivered their therapeutic payload. Inhalation of large porous insulin particles resulted in elevated systemic levels of insulin and suppressed systemic glucose levels for 96 hours, whereas small nonporous insulin particles had this effect for only 4 hours. High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles.</jats:p>

収録刊行物

  • Science

    Science 276 (5320), 1868-1872, 1997-06-20

    American Association for the Advancement of Science (AAAS)

被引用文献 (28)*注記

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