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- Attallah Kappas
- Rockefeller University, New York 10021
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- Mahin D. Maines
- Rockefeller University, New York 10021
書誌事項
- 公開日
- 1976-04-02
- DOI
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- 10.1126/science.1257757
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p>Tin greatly enhances heme breakdown in kidney, thus impairing heme-dependent cellular functions, such as cytochrome P-450 mediated drug biotransformation. This novel action of the metal results from a potent induction effect on heme oxygenase, the enzyme that catalyzes heme oxidation in microsomes. The possible toxicological implications of this tin effect in the kidney merit further investigation.</jats:p>
収録刊行物
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- Science
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Science 192 (4234), 60-62, 1976-04-02
American Association for the Advancement of Science (AAAS)