Discovery and Characterization of Alamandine

DOI Web Site 被引用文献9件
  • Roberto Queiroga Lautner
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Daniel C. Villela
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Rodrigo A. Fraga-Silva
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Neiva Silva
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Thiago Verano-Braga
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Fabiana Costa-Fraga
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Joachim Jankowski
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Vera Jankowski
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Frederico Sousa
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Andreia Alzamora
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Everton Soares
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Claudiane Barbosa
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Frank Kjeldsen
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Aline Oliveira
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Janaina Braga
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Silvia Savergnini
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Gisele Maia
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Antonio Bastos Peluso
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Danielle Passos-Silva
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Anderson Ferreira
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Fabiana Alves
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Almir Martins
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Mohan Raizada
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Renata Paula
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Daisy Motta-Santos
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Friederike Kemplin
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Adriano Pimenta
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Natalia Alenina
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Ruben Sinisterra
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Michael Bader
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Maria Jose Campagnole-Santos
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...
  • Robson A.S. Santos
    From the Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (R.Q.L., D.C.V., R.A.F.-S., N.S., T.V.-B., F.C.-F., A.A., E.S., C.B., A.O., J.B., S.S., G.M., A.B.P., D.P.-S., A.F., F.A., A.M., R.P., D.M.-S., M.J.C-S., R.S.), Department of Morphology (A.F.), Department of Biochemistry and Immunology (A.P.), and Department of Chemistry, National Institute of Science and Technology in Nanobiopharmaceutics (F.S., R.S.), Federal University of Minas...

書誌事項

タイトル別名
  • A Novel Component of the Renin–Angiotensin System

抄録

<jats:sec> <jats:title> <jats:underline>Rationale:</jats:underline> </jats:title> <jats:p>The renin–angiotensin system (RAS) is a key regulator of the cardiovascular system, electrolyte, and water balance. Here, we report identification and characterization of alamandine, a new heptapeptide generated by catalytic action of angiotensin-converting enzyme-2 angiotensin A or directly from angiotensin-(1–7).</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Objective:</jats:underline> </jats:title> <jats:p>To characterize a novel component of the RAS, alamandine.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Methods and Results:</jats:underline> </jats:title> <jats:p> Using mass spectrometry we observed that alamandine circulates in human blood and can be formed from angiotensin-(1–7) in the heart. Alamandine produces several physiological actions that resemble those produced by angiotensin-(1–7), including vasodilation, antifibrosis, antihypertensive, and central effects. Interestingly, our data reveal that its actions are independent of the known vasodilator receptors of the RAS, Mas, and angiotensin II type 2 receptor. Rather, we demonstrate that alamandine acts through the Mas-related G-protein–coupled receptor, member D. Binding of alamandine to Mas-related G-protein–coupled receptor, member D is blocked by D-Pro <jats:sup>7</jats:sup> -angiotensin-(1–7), the Mas-related G-protein–coupled receptor, member D ligand β-alanine and PD123319, but not by the Mas antagonist A-779. In addition, oral administration of an inclusion compound of alamandine/β-hydroxypropyl cyclodextrin produced a long-term antihypertensive effect in spontaneously hypertensive rats and antifibrotic effects in isoproterenol-treated rats. Alamandine had no noticeable proliferative or antiproliferative effect in human tumoral cell lines. </jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Conclusions:</jats:underline> </jats:title> <jats:p>The identification of these 2 novel components of the RAS, alamandine and its receptor, provides new insights for the understanding of the physiological and pathophysiological role of the RAS and may help to develop new therapeutic strategies for treating human cardiovascular diseases and other related disorders.</jats:p> </jats:sec>

収録刊行物

  • Circulation Research

    Circulation Research 112 (8), 1104-1111, 2013-04-12

    Ovid Technologies (Wolters Kluwer Health)

被引用文献 (9)*注記

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