Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus
-
- Xuekui Xia
- Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China
-
- Jun Qi
- Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China
-
- Yayue Liu
- School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
-
- Airong Jia
- Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China
-
- Yonggang Zhang
- Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China
-
- Changheng Liu
- Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China
-
- Cuiling Gao
- Shandong Provincial Key Laboratory of Test Technology for Material Chemical Safety, Jinan 250014, China
-
- Zhigang She
- School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
書誌事項
- 公開日
- 2015-03-02
- 権利情報
-
- https://creativecommons.org/licenses/by/4.0/
- DOI
-
- 10.3390/md13031124
- 公開者
- MDPI AG
説明
<jats:p>One new isopimarane diterpene (1), together with two known compounds, 11-deoxydiaporthein A (2) and iso-pimara-8(14),15-diene (3) were isolated from the culture of Epicoccum sp., which was associated with Apostichopus japonicus. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data. The absolute configuration of Compound 1 was deduced by a single-crystal X-ray diffraction experiment using CuKα radiation. In the bioactivity assay, both Compounds 1 and 2 exhibited α-glucosidase inhibitory activity with IC50 values of 4.6 ± 0.1 and 11.9 ± 0.4 μM, respectively. This was the first report on isopimarane diterpenes with α-glucosidase inhibitory activity.</jats:p>
収録刊行物
-
- Marine Drugs
-
Marine Drugs 13 (3), 1124-1132, 2015-03-02
MDPI AG