Association of short‐term memory with a variant within<i> DYX1C1 </i>in developmental dyslexia
抄録
<jats:p> <jats:bold>A substantial genetic contribution in the etiology of developmental dyslexia (DD) has been well documented with independent groups reporting a susceptibility locus on chromosome 15q. After the identification of the<jats:italic> DYX1C1 </jats:italic>gene as a potential candidate for DD, several independent association studies reported controversial results. We performed a family‐based association study to determine whether the<jats:italic> DYX1C1 </jats:italic>single nucleotide polymorphisms (SNPs) that have been associated with DD before, that is SNPs ‘−3GA’ and ‘1249GT’, influence a broader phenotypic definition of DD. A significant linkage disequilibrium was observed with ‘Single Letter Backward Span’ (SLBS) in both single‐marker and haplotype analyses. These results provide further support to the association between DD and<jats:italic> DYX1C1 </jats:italic>and it suggests that the linkage disequilibrium with<jats:italic> DYX1C1 </jats:italic>is more saliently explained in Italian dyslexics by short‐term memory, as measured by ‘SLBS’, than by the categorical diagnosis of DD or other related phenotypes.</jats:bold> </jats:p>
収録刊行物
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- Genes, Brain and Behavior
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Genes, Brain and Behavior 6 (7), 640-646, 2006-11-15
Wiley