Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

DOI Web Site 被引用文献13件
  • Richard Weindruch
    Department of Pathology, University of California Los Angeles, School of Medicine, Los Angeles 90024
  • Roy L. Walford
    Department of Pathology, University of California Los Angeles, School of Medicine, Los Angeles 90024

書誌事項

公開日
1982-03-12
DOI
  • 10.1126/science.7063854
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of "undernutrition without malnutrition." The mice on the restricted diet averaged 10 to 20 percent increases in mean and maximum survival times compared to the control mice. Spontaneous lymphoma was inhibited by the food restriction.</jats:p>

収録刊行物

  • Science

    Science 215 (4538), 1415-1418, 1982-03-12

    American Association for the Advancement of Science (AAAS)

被引用文献 (13)*注記

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