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- A. A. Fienberg
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- N. Hiroi
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- P. G. Mermelstein
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- W.-J. Song
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- G. L. Snyder
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- A. Nishi
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- A. Cheramy
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- J. P. O'Callaghan
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- D. B. Miller
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- D. G. Cole
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- R. Corbett
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- C. N. Haile
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- D. C. Cooper
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- S. P. Onn
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- A. A. Grace
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- C. C. Ouimet
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- F. J. White
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- S. E. Hyman
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- D. J. Surmeier
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- J.-A. Girault
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- E. J. Nestler
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
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- P. Greengard
- A. A. Fienberg, G. L. Snyder, A. Nishi, P. Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA. N. Hiroi, C. N. Haile, E. J. Nestler, Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA. P. G. Mermelstein, W.-J. Song, D. J. Surmeier, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA. A. Cheramy and J...
説明
<jats:p>Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.</jats:p>
収録刊行物
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- Science
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Science 281 (5378), 838-842, 1998-08-07
American Association for the Advancement of Science (AAAS)