Inflammation and cancer: An ancient link with novel potentials

S. Perwez Hussain, Curtis C. Harris

doi:10.1002/ijc.23173

Inflammation and cancer: An ancient link with novel potentials

DOI Web Site Web Site 被引用文献32件

書誌事項

公開日: 2007-09-24

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/ijc.23173

公開者: Wiley

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CiNii Books

説明

<jats:title>Abstract</jats:title><jats:p>Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, <jats:italic>e.g.</jats:italic>, cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post‐translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. © 2007 Wiley‐Liss, Inc.</jats:p>