Multicomponent Reactions, Union of <scp>MCRs</scp> and Beyond

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<jats:title>Abstract</jats:title><jats:p>Multicomponent reactions (<jats:styled-content style="fixed-case">MCRs</jats:styled-content>), which are located between one‐ and two‐component and polymerization reactions, provide a number of valuable conceptual and synthetic advantages over stepwise sequential approaches towards complex and valuable molecules. To address current limitations in the number of <jats:styled-content style="fixed-case">MCRs</jats:styled-content> and the resulting scaffolds, the concept of union of <jats:styled-content style="fixed-case">MCRs</jats:styled-content> was introduced two decades ago by <jats:styled-content style="fixed-case">D</jats:styled-content>ömling and <jats:styled-content style="fixed-case">U</jats:styled-content>gi and is rapidly advancing, as is apparent by several recently published works. <jats:styled-content style="fixed-case">MCR</jats:styled-content> technology is now widely recognized for its impact on drug discovery projects and is strongly endorsed by industry in addition to academia. Clearly, novel scaffolds accessible in few steps including <jats:styled-content style="fixed-case">MCRs</jats:styled-content> will further enhance the field of applications. Additionally, broad expansion of <jats:styled-content style="fixed-case">MCR</jats:styled-content> applications in fields such as imaging, materials science, medical devices, agriculture, or futuristic applications in stem cell therapy and theragnostics or solar energy and superconductivity are predicted.</jats:p>

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