Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration
-
- Curtis Powell
- Molecular and Behavioral Neuroscience Institute,
-
- Ana R. Grant
- Bioinformatics Core, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109
-
- Eli Cornblath
- Molecular and Behavioral Neuroscience Institute,
-
- Daniel Goldman
- Molecular and Behavioral Neuroscience Institute,
抄録
<jats:title>Significance</jats:title> <jats:p>Retinal injury in zebrafish stimulates Müller glia (MG) to undergo a reprogramming event that transitions their identity from quiescent supportive cells to multipotent progenitors capable of repairing the damaged retina. Understanding the mechanisms underlying this reprogramming event may provide insights for stimulating retina regeneration in mammals. Here we report an epigenetic analysis of zebrafish MG, monitoring changes in their genomic methylation levels as they reprogram and generate progenitors. Although we find a changing DNA methylation landscape, our data also suggest that a basal methylation program may facilitate this transition. Interestingly, certain aspects of this basal methylation program are shared with mammals, suggesting they too may acquire progenitor properties under appropriate circumstances.</jats:p>
収録刊行物
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 110 (49), 19814-19819, 2013-11-18
Proceedings of the National Academy of Sciences
