Mapping human brain networks with cortico-cortical evoked potentials
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- Corey J. Keller
- Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, and Feinstein Institute for Medical Research, Manhasset, NY, USA
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- Christopher J. Honey
- Department of Psychology, Princeton University, Princeton, NJ, USA
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- Pierre Mégevand
- Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, and Feinstein Institute for Medical Research, Manhasset, NY, USA
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- Laszlo Entz
- Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
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- Istvan Ulbert
- Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
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- Ashesh D. Mehta
- Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, and Feinstein Institute for Medical Research, Manhasset, NY, USA
Abstract
<jats:p>The cerebral cortex forms a sheet of neurons organized into a network of interconnected modules that is highly expanded in humans and presumably enables our most refined sensory and cognitive abilities. The links of this network form a fundamental aspect of its organization, and a great deal of research is focusing on understanding how information flows within and between different regions. However, an often-overlooked element of this connectivity regards a causal, hierarchical structure of regions, whereby certain nodes of the cortical network may exert greater influence over the others. While this is difficult to ascertain non-invasively, patients undergoing invasive electrode monitoring for epilepsy provide a unique window into this aspect of cortical organization. In this review, we highlight the potential for cortico-cortical evoked potential (CCEP) mapping to directly measure neuronal propagation across large-scale brain networks with spatio-temporal resolution that is superior to traditional neuroimaging methods. We first introduce effective connectivity and discuss the mechanisms underlying CCEP generation. Next, we highlight how CCEP mapping has begun to provide insight into the neural basis of non-invasive imaging signals. Finally, we present a novel approach to perturbing and measuring brain network function during cognitive processing. The direct measurement of CCEPs in response to electrical stimulation represents a potentially powerful clinical and basic science tool for probing the large-scale networks of the human cerebral cortex.</jats:p>
Journal
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- Philosophical Transactions of the Royal Society B: Biological Sciences
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Philosophical Transactions of the Royal Society B: Biological Sciences 369 (1653), 20130528-, 2014-10-05
The Royal Society
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Details 詳細情報について
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- CRID
- 1363388843981407104
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- ISSN
- 14712970
- 09628436
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- Data Source
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- Crossref