Primate Transcript and Protein Expression Levels Evolve Under Compensatory Selection Pressures
-
- Zia Khan
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
-
- Michael J. Ford
- MS Bioworks, LLC, 3950 Varsity Drive, Ann Arbor, MI 48108, USA.
-
- Darren A. Cusanovich
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
-
- Amy Mitrano
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
-
- Jonathan K. Pritchard
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
-
- Yoav Gilad
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
書誌事項
- 公開日
- 2013-11-29
- DOI
-
- 10.1126/science.1242379
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Don't Ape Protein Variation</jats:title> <jats:p> Changes in DNA and messenger RNA (mRNA) expression levels have been used to estimate evolutionary changes between species. However protein expression levels may better reflect selection on divergent and constrained phenotypes. <jats:bold> Khan <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6162" page="1100" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1242379">1100</jats:related-article> , published online 17 October; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6162" page="1052" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1247833">Vogel</jats:related-article> </jats:bold> ) measured the differences among and within species between mRNA expression and protein levels in humans, chimpanzees, and rhesus macaques, identifying protein transcripts that seem to be under lineage-specific constraint between humans and chimpanzees. </jats:p>
収録刊行物
-
- Science
-
Science 342 (6162), 1100-1104, 2013-11-29
American Association for the Advancement of Science (AAAS)
