A Redox Modulatory Mn<sub>3</sub>O<sub>4</sub> Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

DOI Web Site Web Site 1 Citations
  • Namrata Singh
    Department of Inorganic and Physical Chemistry Indian Institute of Science Bangalore- 560012 India
  • Mohammed Azharuddin Savanur
    Department of Biochemistry Indian Institute of Science Bangalore- 560012 India
  • Shubhi Srivastava
    Department of Biochemistry Indian Institute of Science Bangalore- 560012 India
  • Patrick D'Silva
    Department of Biochemistry Indian Institute of Science Bangalore- 560012 India
  • Govindasamy Mugesh
    Department of Inorganic and Physical Chemistry Indian Institute of Science Bangalore- 560012 India

Description

<jats:title>Abstract</jats:title><jats:p>Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology‐dependent. The redox modulatory effect of Mn<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)‐like cellular model, indicating that manganese‐based nanomaterials having multi‐enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS‐mediated neurological disorders.</jats:p>

Journal

Citations (1)*help

See more

Report a problem

Back to top