TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa
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- Laurye Van Maele
- Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille , Orléans ,
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- Christophe Carnoy
- Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille , Orléans ,
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- Delphine Cayet
- Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille , Orléans ,
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- Pascal Songhet
- Institute of Microbiology, Eidgenössiche Technische Hochschule Zurich , Zurich ,
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- Laure Dumoutier
- Ludwig Institute for Cancer Research, Brussels Branch, de Duve Institute, Université catholique de Louvain , Brussels ,
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- Isabel Ferrero
- Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne , Epalinges ,
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- Laure Janot
- University of Orléans , Orléans ,
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- François Erard
- University of Orléans , Orléans ,
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- Julie Bertout
- Institut Fédératif de Recherche 142 , Lille ,
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- Hélène Leger
- Université Lille Nord de France , Orléans ,
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- Florent Sebbane
- Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille , Orléans ,
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- Arndt Benecke
- Université Lille Nord de France , Orléans ,
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- Jean-Christophe Renauld
- Ludwig Institute for Cancer Research, Brussels Branch, de Duve Institute, Université catholique de Louvain , Brussels ,
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- Wolf-Dietrich Hardt
- Institute of Microbiology, Eidgenössiche Technische Hochschule Zurich , Zurich ,
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- Bernhard Ryffel
- University of Orléans , Orléans ,
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- Jean-Claude Sirard
- Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille , Orléans ,
書誌事項
- 公開日
- 2010-07
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.4049/jimmunol.1000115
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>In adaptive immunity, Th17 lymphocytes produce the IL-17 and IL-22 cytokines that stimulate mucosal antimicrobial defenses and tissue repair. In this study, we observed that the TLR5 agonist flagellin induced swift and transient transcription of genes encoding IL-17 and IL-22 in lymphoid, gut, and lung tissues. This innate response also temporarily enhanced the expression of genes associated with the antimicrobial Th17 signature. The source of the Th17-related cytokines was identified as novel populations of CD3negCD127+ immune cells among which CD4-expressing cells resembling lymphoid tissue inducer cells. We also demonstrated that dendritic cells are essential for expression of Th17-related cytokines and so for stimulation of innate cells. These data define that TLR-induced activation of CD3negCD127+ cells and production of Th17-related cytokines may be crucial for the early defenses against pathogen invasion of host tissues.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 185 (2), 1177-1185, 2010-07
Oxford University Press (OUP)