A biological profile for diagnosis and outcome of COVID-19 patients
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- Mehdi Khourssaji
- Department of Clinical Biochemistry , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Virginie Chapelle
- Department of Hematology , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Anton Evenepoel
- Department of Hematology , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Leila Belkhir
- Department of Infectious Diseases , Cliniques Universitaires St-Luc and Université catholique de Louvain , Brussels , Belgium
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- Jean Cyr Yombi
- Department of Infectious Diseases , Cliniques Universitaires St-Luc and Université catholique de Louvain , Brussels , Belgium
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- Marie-Astrid van Dievoet
- Department of Hematology , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Pascale Saussoy
- Department of Hematology , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Emmanuel Coche
- Department of Radiology , Cliniques Universitaires St-Luc and Université catholique de Louvain , Brussels , Belgium
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- Catherine Fillée
- Department of Clinical Biochemistry , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Stefan N. Constantinescu
- Signal Transduction Pole, SIGN , de Duve Institute , Brussels , Belgium
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- Hector Rodriguez-Villalobos
- Department of Microbiology , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Jean-Philippe Defour
- Department of Hematology , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
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- Damien Gruson
- Department of Clinical Biochemistry , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium
Description
<jats:title>Abstract</jats:title> <jats:sec id="j_cclm-2020-0626_abs_001"> <jats:title>Objectives</jats:title> <jats:p>As severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) pandemic is increasing its victims on a global scale with recurring outbreaks, it remains of outmost importance to rapidly identify people requiring an intensive care unit (ICU) hospitalization. The aim of this study was to identify Coronavirus Disease 2019 (COVID-19) biomarkers, to investigate their correlation with disease severity and to evaluate their usefulness for follow-up.</jats:p> </jats:sec> <jats:sec id="j_cclm-2020-0626_abs_002"> <jats:title>Methods</jats:title> <jats:p>Fifty patients diagnosed with SARS-Cov-2 were included in March 2020. Clinical and biological data were collected at admission, during hospitalization and one month after discharge. Patients were divided into two severity groups: non-ICU (28) and ICU and/or death (22) to stratify the risk.</jats:p> </jats:sec> <jats:sec id="j_cclm-2020-0626_abs_003"> <jats:title>Results</jats:title> <jats:p>Blood parameters in COVID-19 patients at admission showed increased C-reactive protein (CRP) (100%), ferritin (92%), lactate dehydrogenase (LDH) (80%), white blood cell (WBC) count (26%) with lymphopenia (52%) and eosinopenia (98%). There were significant differences in levels of CRP, ferritin, D-dimers, fibrinogen, lymphocyte count, neutrophil count and neutrophil-to-lymphocyte ratio (NLR) among the two severity groups. Mapping of biomarker’s kinetics distinguished early and late parameters. CRP, ferritin, LDH, lymphopenia and eosinopenia were present upon admission with a peak at the first week. Late biomarkers such as anemia, neutrophilia and elevated liver biomarkers appeared after one week with a peak at three weeks of hospitalization.</jats:p> </jats:sec> <jats:sec id="j_cclm-2020-0626_abs_004"> <jats:title>Conclusions</jats:title> <jats:p>We confirmed that high-values of CRP, NLR, D-dimers, ferritin as well as lymphopenia and eosinopenia were consistently found and are good markers for risk stratification. Kinetics of these biomarkers correlate well with COVID-19 severity. Close monitoring of early and late biomarkers is crucial in the management of critical patients to avoid preventable deaths.</jats:p> </jats:sec>
Journal
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- Clinical Chemistry and Laboratory Medicine (CCLM)
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Clinical Chemistry and Laboratory Medicine (CCLM) 58 (12), 2141-2150, 2020-10-15
Walter de Gruyter GmbH
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Details 詳細情報について
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- CRID
- 1363388844222190848
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- ISSN
- 14374331
- 14346621
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- Data Source
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- Crossref