Resident memory CD8 T cells persist for years in human small intestine

DOI PDF 2 Citations
  • Raquel Bartolomé-Casado
    Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
  • Ole J.B. Landsverk
    Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
  • Sudhir Kumar Chauhan
    Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
  • Lisa Richter
    Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
  • Danh Phung
    Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
  • Victor Greiff
    Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
  • Louise F. Risnes
    Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway 5
  • Ying Yao
    Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
  • Ralf S. Neumann
    Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
  • Sheraz Yaqub
    Department of Gastrointestinal Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway 7
  • Ole Øyen
    Department of Transplantation Medicine, Section for Transplant Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway 8
  • Rune Horneland
    Department of Transplantation Medicine, Section for Transplant Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway 8
  • Einar Martin Aandahl
    Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway 2
  • Vemund Paulsen
    Department of Gastroenterology, Oslo University Hospital, Rikshospitalet, Oslo, Norway 9
  • Ludvig M. Sollid
    Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
  • Shuo-Wang Qiao
    Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
  • Espen S. Baekkevold
    Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
  • Frode L. Jahnsen
    Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1

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<jats:p>Resident memory CD8 T (Trm) cells have been shown to provide effective protective responses in the small intestine (SI) in mice. A better understanding of the generation and persistence of SI CD8 Trm cells in humans may have implications for intestinal immune-mediated diseases and vaccine development. Analyzing normal and transplanted human SI, we demonstrated that the majority of SI CD8 T cells were bona fide CD8 Trm cells that survived for &gt;1 yr in the graft. Intraepithelial and lamina propria CD8 Trm cells showed a high clonal overlap and a repertoire dominated by expanded clones, conserved both spatially in the intestine and over time. Functionally, lamina propria CD8 Trm cells were potent cytokine producers, exhibiting a polyfunctional (IFN-γ+ IL-2+ TNF-α+) profile, and efficiently expressed cytotoxic mediators after stimulation. These results suggest that SI CD8 Trm cells could be relevant targets for future oral vaccines and therapeutic strategies for gut disorders.</jats:p>

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