Genome Sequence of <i>Aeromonas hydrophila</i> ATCC 7966 <sup>T</sup> : Jack of All Trades
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- Rekha Seshadri
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Sam W. Joseph
- Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742
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- Ashok K. Chopra
- Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555
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- Jian Sha
- Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555
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- Jonathan Shaw
- Division of Genomic Medicine, Section of Functional Genomics, University of Sheffield Medical School, Sheffield, S10 2RX, United Kingdom
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- Joerg Graf
- Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269
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- Daniel Haft
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Martin Wu
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Qinghu Ren
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- M. J. Rosovitz
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Ramana Madupu
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Luke Tallon
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Mary Kim
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Shaohua Jin
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- Hue Vuong
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
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- O. Colin Stine
- Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201
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- Afsar Ali
- Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201
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- Amy J. Horneman
- Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201
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- John F. Heidelberg
- The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850
説明
<jats:title>ABSTRACT</jats:title> <jats:p> The complete genome of <jats:italic>Aeromonas hydrophila</jats:italic> ATCC 7966 <jats:sup>T</jats:sup> was sequenced. <jats:italic>Aeromonas</jats:italic> , a ubiquitous waterborne bacterium, has been placed by the Environmental Protection Agency on the Contaminant Candidate List because of its potential to cause human disease. The 4.7-Mb genome of this emerging pathogen shows a physiologically adroit organism with broad metabolic capabilities and considerable virulence potential. A large array of virulence genes, including some identified in clinical isolates of <jats:italic>Aeromonas</jats:italic> spp. or <jats:italic>Vibrio</jats:italic> spp., may confer upon this organism the ability to infect a wide range of hosts. However, two recognized virulence markers, a type III secretion system and a lateral flagellum, that are reported in other <jats:italic>A. hydrophila</jats:italic> strains are not identified in the sequenced isolate, ATCC 7966 <jats:sup>T</jats:sup> . Given the ubiquity and free-living lifestyle of this organism, there is relatively little evidence of fluidity in terms of mobile elements in the genome of this particular strain. Notable aspects of the metabolic repertoire of <jats:italic>A. hydrophila</jats:italic> include dissimilatory sulfate reduction and resistance mechanisms (such as thiopurine reductase, arsenate reductase, and phosphonate degradation enzymes) against toxic compounds encountered in polluted waters. These enzymes may have bioremediative as well as industrial potential. Thus, the <jats:italic>A. hydrophila</jats:italic> genome sequence provides valuable insights into its ability to flourish in both aquatic and host environments. </jats:p>
収録刊行物
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- Journal of Bacteriology
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Journal of Bacteriology 188 (23), 8272-8282, 2006-12
American Society for Microbiology