Innate responses of B cells

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Abstract

<jats:title>Abstract</jats:title><jats:p>In this review, we describe the non‐antibody‐mediated functions of B cells within the immune system. In addition to antibody production, B cells also present antigen to T cells, programme T cell differentiation and regulate effector T cell responses and much of this is mediated by the cytokines they make. We focus on the potential of B cells to perform these functions simply as a result of activation <jats:italic>via</jats:italic> ‘innate’ receptors (<jats:italic>e.g.</jats:italic> Toll‐like receptors) and often independently of BCR ligation. We feel an appreciation of these broad and often antigen‐nonspecific functions is important at a time when there is an increasing use of B cell depletion as a therapy for autoimmune disease.</jats:p>

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