Mechanism of Hypergammaglobulinemia by HIV Infection: Circulating Memory B-Cell Reduction with Plasmacytosis
書誌事項
- 公開日
- 2001-08
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
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- 10.1006/clim.2001.5054
- 公開者
- Elsevier BV
この論文をさがす
説明
The mechanism of hypergammaglobulinemia in patients infected with HIV has remained unclear in spite of the identification of a reduction of CD4+ T cells. The amounts of CD27+ memory B cells were remarkably reduced in the peripheral blood and immunoglobulin (Ig) production was diminished in HIV-infected patients. Some of the freshly isolated patients' T cells expressed the CD70 (CD27 ligand) on the surface and the CD70 expression on both of the CD4+ and CD8+ T cells was greatly enhanced by various stimuli. It was also striking that plasmacytosis was observed in patients' bone marrow. Thus, our findings suggest that CD70 expressed spontaneously or by activation on T cells of HIV-infected patients stimulates memory B cells via CD27 and promotes their differentiation into plasma cells, resulting in the elevation of serum Ig levels and the elimination of circulating memory B cells in HIV-infected patients.
収録刊行物
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- Clinical Immunology
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Clinical Immunology 100 (2), 250-259, 2001-08
Elsevier BV