Increased fetal lung <scp>T2</scp> signal is not due to increasing surfactant concentration: an <i>in vitro</i> T2 mapping analysis

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<jats:title>Abstract</jats:title><jats:sec><jats:title>Object</jats:title><jats:p>The aim of this study was to perform <jats:italic>in vitro</jats:italic> T2 mapping of serial dilutions of pharmaceutical surfactant.</jats:p></jats:sec><jats:sec><jats:title>Materials and methods</jats:title><jats:p><jats:italic>Magnetic resonance imaging.</jats:italic> Magnetic resonance scanning was performed on serial dilutions of surfactant on large bore clinical magnets at a field strength of 1.5 T Philips and 3.0 T (Achieva TX, Philips Healthcare, the Netherlands).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The curves demonstrate a small increasing trend between surfactant concentration and R2 (shortened T2's), with a 7.3% increase in R2 for each doubling of surfactant concentration (95% confidence interval: 6.1–8.6%, <jats:italic>p</jats:italic> < 0.001).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The increasing lung/liver T2 signal ratio seen in fetal lungs with increasing gestational age is not due to increasing surfactant concentration. © 2016 John Wiley & Sons, Ltd.</jats:p></jats:sec>

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