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- Zachary D. Dalebroux
- Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan
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- Sarah L. Svensson
- Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
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- Erin C. Gaynor
- Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
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- Michele S. Swanson
- Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan
説明
<jats:sec><jats:title>SUMMARY</jats:title><jats:p>Like for all microbes, the goal of every pathogen is to survive and replicate. However, to overcome the formidable defenses of their hosts, pathogens are also endowed with traits commonly associated with virulence, such as surface attachment, cell or tissue invasion, and transmission. Numerous pathogens couple their specific virulence pathways with more general adaptations, like stress resistance, by integrating dedicated regulators with global signaling networks. In particular, many of nature's most dreaded bacteria rely on nucleotide alarmones to cue metabolic disturbances and coordinate survival and virulence programs. Here we discuss how components of the stringent response contribute to the virulence of a wide variety of pathogenic bacteria.</jats:p></jats:sec>
収録刊行物
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- Microbiology and Molecular Biology Reviews
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Microbiology and Molecular Biology Reviews 74 (2), 171-199, 2010-06
American Society for Microbiology